Algorithmic description of pyramidal neuron populations from mouse neocortex
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چکیده
منابع مشابه
Pyramidal Neurons Are Not Generalizable Building Blocks of Cortical Networks
A key challenge in cortical neuroscience is to gain a comprehensive understanding of how pyramidal neuron heterogeneity across different areas and species underlies the functional specialization of individual neurons, networks, and areas. Comparative studies have been important in this endeavor, providing data relevant to the question of which of the many inherent properties of individual pyram...
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The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investig...
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The formation of a laminar structure such as the mammalian neocortex relies on the coordinated migration of different subtypes of excitatory pyramidal neurons in specific layers. Cyclin-dependent kinase 5 (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investig...
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A subset of pyramidal neurons in layer 5 of the mammalian neocortex can fire action potentials in brief, high-frequency bursts while others fire spikes at regularly spaced intervals. Here we show that individual layer 5 pyramidal neurons in acute slices from mouse primary motor cortex can adopt both regular and burst spiking patterns. During constant current injection at the soma, neurons displ...
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Two models of the neocortex are developed to study normal and pathological neuronal activity. One model contains a detailed description of a neocortical microcolumn represented by 656 neurons, including superficial and deep pyramidal cells, four types of inhibitory neurons and realistic synaptic contacts. Simulations show that neurons of a given type exhibit similar behavior in this detailed mo...
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تاریخ انتشار 2011